{"id":3948,"date":"2024-09-13T09:17:44","date_gmt":"2024-09-13T01:17:44","guid":{"rendered":"https:\/\/www.360mdi.com\/archives\/3948"},"modified":"2024-09-13T09:17:44","modified_gmt":"2024-09-13T01:17:44","slug":"%e4%b8%89%e4%b8%81%e5%9f%ba%e6%b0%a7%e5%8c%96%e9%94%a1%e5%9c%a8%e6%9c%89%e6%9c%ba%e5%90%88%e6%88%90%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%e5%8f%8a%e5%8f%8d%e5%ba%94%e6%9c%ba%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.360mdi.com\/archives\/3948","title":{"rendered":"\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u5e94\u7528\u53ca\u53cd\u5e94\u673a\u5236"},"content":{"rendered":"

\u5f15\u8a00
\n\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u662f\u4e00\u79cd\u91cd\u8981\u7684\u6709\u673a\u91d1\u5c5e\u5316\u5408\u7269\uff0c\u5728\u6709\u673a\u5408\u6210\u4e2d\u5177\u6709\u591a\u79cd\u5e94\u7528\u3002\u5b83\u5e38\u7528\u4e8e\u50ac\u5316\u6216\u53c2\u4e0e\u5404\u79cd\u6709\u673a\u5316\u5b66\u53cd\u5e94\uff0c\u5982Stille\u5076\u8054\u53cd\u5e94\u3001Heck\u53cd\u5e94\u7b49\u3002\u672c\u6587\u5c06\u63a2\u8ba8\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u4e3b\u8981\u5e94\u7528\u9886\u57df\uff0c\u5e76\u8be6\u7ec6\u5206\u6790\u5176\u5728\u7279\u5b9a\u53cd\u5e94\u4e2d\u7684\u673a\u7406\u3002<\/p>\n

\u4e00\u3001\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u57fa\u672c\u6027\u8d28
\n\u4e09\u4e01\u57fa\u6c27\u5316\u9521\uff08C12H27SnO\uff09\uff0c\u5206\u5b50\u91cf\u7ea6\u4e3a289.67 g\/mol\uff0c\u662f\u4e00\u79cd\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u6db2\u4f53\u3002\u5b83\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\uff0c\u53ef\u4ee5\u6eb6\u4e8e\u591a\u79cd\u6709\u673a\u6eb6\u5242\uff0c\u5982\u4e59\u919a\u3001\u82ef\u7b49\u3002\u7531\u4e8e\u5176\u72ec\u7279\u7684\u5316\u5b66\u6027\u8d28\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u5728\u6709\u673a\u5408\u6210\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u53cd\u5e94\u6d3b\u6027\u3002<\/p>\n

\u4e8c\u3001\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u5e94\u7528
\n2.1 Stille\u5076\u8054\u53cd\u5e94
\nStille\u5076\u8054\u53cd\u5e94\u662f\u5229\u7528\u6709\u673a\u9521\u8bd5\u5242\u4e0e\u5364\u4ee3\u70c3\u5728\u94af\u50ac\u5316\u5242\u5b58\u5728\u4e0b\u8fdb\u884c\u4ea4\u53c9\u5076\u8054\u7684\u4e00\u79cd\u65b9\u6cd5\u3002\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u4f5c\u4e3a\u4e00\u79cd\u6709\u673a\u9521\u8bd5\u5242\uff0c\u5728\u8be5\u53cd\u5e94\u4e2d\u53ef\u4ee5\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u6216\u8f85\u52a9\u8bd5\u5242\u53c2\u4e0e\u53cd\u5e94\u3002\u8fd9\u79cd\u5076\u8054\u53cd\u5e94\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5408\u6210\u590d\u6742\u5206\u5b50\u7ed3\u6784\uff0c\u5c24\u5176\u662f\u836f\u7269\u5316\u5b66\u548c\u5929\u7136\u4ea7\u7269\u5408\u6210\u4e2d\u3002<\/p>\n

2.2 Heck\u53cd\u5e94
\nHeck\u53cd\u5e94\u662f\u6307\u70ef\u70c3\u4e0e\u82b3\u57fa\u5364\u5316\u7269\u6216\u6742\u73af\u5364\u5316\u7269\u5728\u94af\u50ac\u5316\u5242\u7684\u5b58\u5728\u4e0b\u8fdb\u884c\u5076\u8054\u751f\u6210\u53d6\u4ee3\u70ef\u70c3\u7684\u53cd\u5e94\u3002\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u6709\u65f6\u7528\u4f5c\u52a9\u5242\uff0c\u4ee5\u63d0\u9ad8\u53cd\u5e94\u7684\u9009\u62e9\u6027\u548c\u4ea7\u7387\u3002<\/p>\n

2.3 \u5176\u4ed6\u6709\u673a\u5408\u6210\u53cd\u5e94
\n\u9664\u4e86\u4e0a\u8ff0\u4e24\u79cd\u4e3b\u8981\u5e94\u7528\u5916\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u8fd8\u53c2\u4e0e\u4e86\u5176\u4ed6\u7c7b\u578b\u7684\u6709\u673a\u5408\u6210\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a<\/p>\n

Suzuki\u5076\u8054\u53cd\u5e94\uff1a\u867d\u7136\u901a\u5e38\u4f7f\u7528\u6709\u673a\u787c\u9178\u916f\u4f5c\u4e3a\u4eb2\u7535\u8bd5\u5242\uff0c\u4f46\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u4e5f\u53ef\u7528\u4e8e\u7c7b\u4f3c\u7684\u5076\u8054\u8fc7\u7a0b\u3002
\nSonogashira\u5076\u8054\u53cd\u5e94\uff1a\u5728\u5f62\u6210\u78b3-\u78b3\u952e\u7684\u8fc7\u7a0b\u4e2d\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u53ef\u4ee5\u4f5c\u4e3a\u8f85\u52a9\u8bd5\u5242\u6765\u6539\u5584\u53cd\u5e94\u6761\u4ef6\u3002
\n\u4e09\u3001\u53cd\u5e94\u673a\u5236
\n3.1 Stille\u5076\u8054\u53cd\u5e94\u673a\u5236
\n\u5728Stille\u5076\u8054\u53cd\u5e94\u4e2d\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u4f5c\u7528\u673a\u5236\u5982\u4e0b\uff1a<\/p>\n

\u914d\u4f4d\u9636\u6bb5\uff1a\u94af\u50ac\u5316\u5242\u9996\u5148\u4e0e\u5364\u4ee3\u70c3\u914d\u4f4d\uff0c\u5f62\u6210\u94af(II)\u914d\u5408\u7269\u3002
\n\u8f6c\u91d1\u5c5e\u5316\uff1a\u63a5\u4e0b\u6765\uff0c\u6709\u673a\u9521\u8bd5\u5242\uff08\u5982\u4e09\u4e01\u57fa\u6c27\u5316\u9521\uff09\u4e0e\u94af\u914d\u5408\u7269\u53d1\u751f\u8f6c\u91d1\u5c5e\u5316\u53cd\u5e94\uff0c\u751f\u6210\u94af-\u6709\u673a\u4e2d\u95f4\u4f53\u3002
\n\u03b2-\u6d88\u9664\uff1a\u968f\u540e\uff0c\u94af-\u6709\u673a\u4e2d\u95f4\u4f53\u53d1\u751f\u03b2-\u6d88\u9664\u53cd\u5e94\uff0c\u91ca\u653e\u51fa\u4e00\u4e2a\u65b0\u7684\u78b3-\u78b3\u53cc\u952e\u3002
\n\u6c27\u5316\u52a0\u6210\uff1a\u540e\uff0c\u901a\u8fc7\u94af\u7684\u6c27\u5316\u52a0\u6210\uff0c\u751f\u6210\u76ee\u6807\u4ea7\u7269\u5e76\u518d\u751f\u94af\u50ac\u5316\u5242\u3002
\n3.2 Heck\u53cd\u5e94\u673a\u5236
\n\u5728Heck\u53cd\u5e94\u4e2d\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u4f5c\u4e3a\u8f85\u52a9\u8bd5\u5242\u53ef\u80fd\u53c2\u4e0e\u7684\u6b65\u9aa4\u5305\u62ec\uff1a<\/p>\n

\u94af\u50ac\u5316\u5242\u6d3b\u5316\uff1a\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u53ef\u80fd\u5e2e\u52a9\u94af\u50ac\u5316\u5242\u66f4\u6709\u6548\u5730\u6d3b\u5316\u5364\u4ee3\u70c3\u3002
\n\u4fc3\u8fdb\u78b3-\u78b3\u952e\u5f62\u6210\uff1a\u901a\u8fc7\u6539\u53d8\u53cd\u5e94\u4f53\u7cfb\u4e2d\u7684\u7535\u5b50\u4e91\u5bc6\u5ea6\u5206\u5e03\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u53ef\u4ee5\u4fc3\u8fdb\u78b3-\u78b3\u952e\u7684\u5f62\u6210\u3002
\n\u56db\u3001\u73af\u5883\u4e0e\u5b89\u5168\u8003\u8651
\n\u5c3d\u7ba1\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u5728\u6709\u673a\u5408\u6210\u4e2d\u6709\u5e7f\u6cdb\u5e94\u7528\uff0c\u4f46\u5176\u6f5c\u5728\u7684\u73af\u5883\u548c\u5065\u5eb7\u98ce\u9669\u4e0d\u5bb9\u5ffd\u89c6\u3002\u9521\u5316\u5408\u7269\u53ef\u80fd\u5bf9\u6c34\u751f\u751f\u7269\u6709\u6bd2\u6027\uff0c\u5e76\u4e14\u5728\u4e0d\u5f53\u5904\u7406\u7684\u60c5\u51b5\u4e0b\u53ef\u80fd\u4f1a\u5bf9\u73af\u5883\u9020\u6210\u6c61\u67d3\u3002\u56e0\u6b64\uff0c\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u5e94\u4e25\u683c\u9075\u5b88\u76f8\u5173\u7684\u5b89\u5168\u64cd\u4f5c\u89c4\u7a0b\uff0c\u5e76\u91c7\u53d6\u9002\u5f53\u7684\u9632\u62a4\u63aa\u65bd\u3002<\/p>\n

\u7ed3\u8bba
\n\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u4f5c\u4e3a\u4e00\u79cd\u591a\u529f\u80fd\u7684\u6709\u673a\u91d1\u5c5e\u8bd5\u5242\uff0c\u5728\u73b0\u4ee3\u6709\u673a\u5408\u6210\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\u3002\u901a\u8fc7\u5bf9\u5b83\u7684\u6df1\u5165\u7406\u89e3\u548c\u5408\u7406\u5e94\u7528\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u63a8\u52a8\u65b0\u836f\u7814\u53d1\u3001\u65b0\u6750\u6599\u5408\u6210\u7b49\u9886\u57df\u7684\u53d1\u5c55\u3002\u7136\u800c\uff0c\u5728\u4eab\u53d7\u5176\u5e26\u6765\u7684\u4fbf\u5229\u7684\u540c\u65f6\uff0c\u4e5f\u5e94\u6ce8\u610f\u5176\u53ef\u80fd\u5e26\u6765\u7684\u73af\u5883\u548c\u5065\u5eb7\u98ce\u9669\uff0c\u91c7\u53d6\u79ef\u6781\u63aa\u65bd\u51cf\u5c11\u8d1f\u9762\u5f71\u54cd\u3002<\/p>\n

\u6269\u5c55\u9605\u8bfb\uff1a<\/p>\n

cyclohexylamine<\/u><\/a><\/p>\n

Tetrachloroethylene Perchloroethylene CAS:127-18-4<\/u><\/a><\/p>\n

NT CAT DMDEE<\/u><\/a><\/p>\n

NT CAT PC-5<\/u><\/a><\/p>\n

N-Methylmorpholine<\/u><\/a><\/p>\n

4-Formylmorpholine<\/u><\/a><\/p>\n

Toyocat TE tertiary amine catalyst Tosoh<\/u><\/a><\/p>\n

Toyocat RX5 catalyst trimethylhydroxyethyl ethylenediamine Tosoh<\/u><\/a><\/p>\n

NT CAT DMP-30<\/u><\/a><\/p>\n

NT CAT DMEA<\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u5f15\u8a00 \u4e09\u4e01\u57fa\u6c27\u5316\u9521\u662f\u4e00\u79cd\u91cd\u8981\u7684\u6709\u673a\u91d1\u5c5e\u5316\u5408\u7269\uff0c\u5728\u6709\u673a\u5408\u6210\u4e2d\u5177\u6709\u591a\u79cd\u5e94\u7528\u3002\u5b83\u5e38\u7528\u4e8e\u50ac\u5316\u6216\u53c2\u4e0e\u5404\u79cd\u6709\u673a\u5316\u5b66\u53cd\u5e94\uff0c\u5982Stille\u5076\u8054\u53cd\u5e94\u3001Heck\u53cd\u5e94\u7b49\u3002\u672c\u6587\u5c06\u63a2\u8ba8\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u4e3b\u8981\u5e94\u7528\u9886\u57df\uff0c\u5e76\u8be6\u7ec6\u5206\u6790\u5176\u5728\u7279\u5b9a\u53cd\u5e94\u4e2d\u7684\u673a\u7406\u3002 \u4e00\u3001\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u57fa\u672c\u6027\u8d28 \u4e09\u4e01\u57fa\u6c27\u5316\u9521\uff08C12H27SnO\uff09\uff0c\u5206\u5b50\u91cf\u7ea6\u4e3a289.67 g\/mol\uff0c\u662f\u4e00\u79cd\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u6db2\u4f53\u3002\u5b83\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\uff0c\u53ef\u4ee5\u6eb6\u4e8e\u591a\u79cd\u6709\u673a\u6eb6\u5242\uff0c\u5982\u4e59\u919a\u3001\u82ef\u7b49\u3002\u7531\u4e8e\u5176\u72ec\u7279\u7684\u5316\u5b66\u6027\u8d28\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u5728\u6709\u673a\u5408\u6210\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u53cd\u5e94\u6d3b\u6027\u3002 \u4e8c\u3001\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u5e94\u7528 2.1 Stille\u5076\u8054\u53cd\u5e94 Stille\u5076\u8054\u53cd\u5e94\u662f\u5229\u7528\u6709\u673a\u9521\u8bd5\u5242\u4e0e\u5364\u4ee3\u70c3\u5728\u94af\u50ac\u5316\u5242\u5b58\u5728\u4e0b\u8fdb\u884c\u4ea4\u53c9\u5076\u8054\u7684\u4e00\u79cd\u65b9\u6cd5\u3002\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u4f5c\u4e3a\u4e00\u79cd\u6709\u673a\u9521\u8bd5\u5242\uff0c\u5728\u8be5\u53cd\u5e94\u4e2d\u53ef\u4ee5\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u6216\u8f85\u52a9\u8bd5\u5242\u53c2\u4e0e\u53cd\u5e94\u3002\u8fd9\u79cd\u5076\u8054\u53cd\u5e94\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5408\u6210\u590d\u6742\u5206\u5b50\u7ed3\u6784\uff0c\u5c24\u5176\u662f\u836f\u7269\u5316\u5b66\u548c\u5929\u7136\u4ea7\u7269\u5408\u6210\u4e2d\u3002 2.2 Heck\u53cd\u5e94 Heck\u53cd\u5e94\u662f\u6307\u70ef\u70c3\u4e0e\u82b3\u57fa\u5364\u5316\u7269\u6216\u6742\u73af\u5364\u5316\u7269\u5728\u94af\u50ac\u5316\u5242\u7684\u5b58\u5728\u4e0b\u8fdb\u884c\u5076\u8054\u751f\u6210\u53d6\u4ee3\u70ef\u70c3\u7684\u53cd\u5e94\u3002\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u6709\u65f6\u7528\u4f5c\u52a9\u5242\uff0c\u4ee5\u63d0\u9ad8\u53cd\u5e94\u7684\u9009\u62e9\u6027\u548c\u4ea7\u7387\u3002 2.3 \u5176\u4ed6\u6709\u673a\u5408\u6210\u53cd\u5e94 \u9664\u4e86\u4e0a\u8ff0\u4e24\u79cd\u4e3b\u8981\u5e94\u7528\u5916\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u8fd8\u53c2\u4e0e\u4e86\u5176\u4ed6\u7c7b\u578b\u7684\u6709\u673a\u5408\u6210\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a Suzuki\u5076\u8054\u53cd\u5e94\uff1a\u867d\u7136\u901a\u5e38\u4f7f\u7528\u6709\u673a\u787c\u9178\u916f\u4f5c\u4e3a\u4eb2\u7535\u8bd5\u5242\uff0c\u4f46\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u4e5f\u53ef\u7528\u4e8e\u7c7b\u4f3c\u7684\u5076\u8054\u8fc7\u7a0b\u3002 Sonogashira\u5076\u8054\u53cd\u5e94\uff1a\u5728\u5f62\u6210\u78b3-\u78b3\u952e\u7684\u8fc7\u7a0b\u4e2d\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u53ef\u4ee5\u4f5c\u4e3a\u8f85\u52a9\u8bd5\u5242\u6765\u6539\u5584\u53cd\u5e94\u6761\u4ef6\u3002 \u4e09\u3001\u53cd\u5e94\u673a\u5236 3.1 Stille\u5076\u8054\u53cd\u5e94\u673a\u5236 \u5728Stille\u5076\u8054\u53cd\u5e94\u4e2d\uff0c\u4e09\u4e01\u57fa\u6c27\u5316\u9521\u7684\u4f5c\u7528\u673a\u5236\u5982\u4e0b\uff1a \u914d\u4f4d\u9636\u6bb5\uff1a\u94af\u50ac\u5316\u5242\u9996\u5148\u4e0e\u5364\u4ee3\u70c3\u914d\u4f4d\uff0c\u5f62\u6210\u94af(II)\u914d\u5408 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[19],"tags":[1412],"_links":{"self":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts\/3948"}],"collection":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/comments?post=3948"}],"version-history":[{"count":0,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts\/3948\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/media?parent=3948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/categories?post=3948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/tags?post=3948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}